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THE REVERSE BREAK-UP

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New Target for Treating Heart Failure Identified by Penn Medicine Researchers

New study is a continuation of research conducted two years ago on how MTs are involved in regulating the heartbeat.

“These findings provide compelling evidence from human samples for a new therapeutic target for heart disease,” said senior author Ben Prosser, PhD , an assistant professor of Physiology. The Penn investigators aim to develop therapies that seek out the damaged MTs to reverse their harmful influence.

By suppressing impaired MTs, the team improved heart muscle cell function in damaged human cells. Normally, MTs of the cell’s inner support system have diverse structural and signaling roles. Alterations in this network have been suggested to contribute to heart disease. Recent studies suggest that chemical changes to the MTs, called detyrosination (the removal of a tyrosine chemical group), control the mechanics of heart beats. Detyrosinated MTs provide resistance that can impede the motion of contracting heart muscle cells.

Temple researchers reverse cognitive impairments in mice with dementia

(Philadelphia, PA) - Reversing memory deficits and impairments in spatial learning is a major goal in the field of dementia research. A lack of knowledge about cellular pathways critical to the development of dementia, however, has stood in the way of significant clinical advance. But now, researchers at the Lewis Katz School of Medicine at Temple University (LKSOM) are breaking through that barrier. They show, for the first time in an animal model, that tau pathology - the second-most important lesion in the brain in patients with Alzheimer's disease - can be reversed by a drug.

"We show that we can intervene after disease is established and pharmacologically rescue mice that have tau-induced memory deficits," explained senior investigator Domenico Praticò, MD, Scott Richards North Star Foundation Chair for Alzheimer's Research, Professor in the Departments of Pharmacology and Microbiology, and Director of the Alzheimer's Center at Temple at LKSOM. The study, published

Is there a 3 day rescind law in pennsylvania for motor vehicles?

I bought a motorcycle from another individual and he claimed the bike was in running conditions. When i rode it after that it started to get progressively worse and now it wont run at all. Is there anything in the law that can prevent or reverse this?


You can check your state's lemon laws (which are unlikely to apply to a non-dealer seller), but in general if you are buying something without a warranty, the rule is 'caveat emptor', which means, buyer beware.